Serenity is a quantum chemistry program focused on, but not exclusively for subsystem methods.
Serenity is wirtten in C++ (C++14) and the source code is currently available at:
https://github.com/qcserenity/serenity
Interested developers shoud write an e-mail to Prof. Dr. Johannes Neugebauer in order to get access to the private developers Git repository.
The initial release of Serenity has been published in the Journal of Computational Chemistry, the paper is available online.